Comparative Study between Immunoglobulin and Plasmapheresis in Landry-Guillain-Barré-Strohl Syndrome, Hospital Central San Cristobal 2012-2017

Abstract

Acute inflammatory polyradiculoneuropathy or Landry-Guillain-Barré-Strohl syndrome is an acquired, monophasic, autoimmune disease preceded by an acute respiratory or gastrointestinal infection, which may be viral or bacterial. This can be treated by two means, the administration of human immunoglobulin or a plasma exchange. Objective: To determine the effectiveness of human immunoglobulin and plasmapheresis in Landry-Guillain-Barré-Strohl syndrome in adult patients in the central hospital of San Cristóbal, San Cristóbal municipality, Táchira state, March 2012- April 2017. Methodology: Descriptive, retrospective study, not experimental field. The population consisted of 33 patients according to the inclusion and exclusion criteria. Results: 62.62% of the cases occurred in 2016, the male predominance 63.64%, average age of 40.81 years, the immunotherapy measures used were plasmapheresis 30.30%, immunoglobulin 18.18% and therapy combined 9.09%, patients who used plasmapheresis required less than 3 sessions in 53.85%, the immunoglobulin scheme of 400mg / kg / day in 5 days was used in 83.33%, immunotherapy started the first 7 days of hospitalization in 94.73%, all patients with plasmapheresis or combination therapy were admitted to the ICU, compared to 50% of those who received immunoglobulin, mechanical ventilation was used in 40% plasmapheresis, 50% immunoglobulin and 100% combined therapy, the mortality was 9.09%, the degree of disability 3 according to Hughes at discharge was 60.61% Conclusion: There was no difference between the use of plasmapheresis or immunoglobulin with respect to: hospital stay, motor recovery, residual disability at discharge and mortality