Clinical and laboratory characteristics of patients with COVID-19 hospitalized in intensive care in a locality in Venezuela
Keywords:
COVID-19, risk factors, signs and symptoms, laboratory, public health.Abstract
COVID-19 is a disease that has a varied clinical spectrum from asymptomatic to severe symptoms. Because it is an emerging disease, the continuous contribution of clinical and epidemiological data is convenient for public health. The objective of this research work was to describe the clinical and laboratory characteristics of patients with COVID-19 in intensive care in a Venezuelan region for which there is no information in this regard. The study, a short report, was descriptive and prospective of patients with COVID-19 hospitalized in an intensive care unit, whose sample was 27 patients in whom the following were described: age, sex, clinical parameters, pathological history, laboratory results. , radiological tests and hospitalization data. The findings reveal that the most affected were 52.8±18.6 years old, with a body mass index of 23.1±4.3, diabetic and hypertensive, with abnormal liver enzymes and parameters such as: LDH, CRP, Bun, D-dimer and glycemia, SaO2 of 70 % and in tachypnea. It is concluded that advanced age is an important risk factor, as well as diabetes mellitus and arterial hypertension. That the SaO2 is less than 90 % in those with poor clinical evolution, with a predominance of the bilateral ground glass radiological pattern and alteration of liver enzymes (towards an increase), as well as for LDH, CRP, fibrinogen, BUN, D-dimer , glycemia and leukocytes.
References
Bastidas, G., & Bastidas-Delgado, G. (2020). Covid-19 in pandemic and outbreak prevention. Family Care, 27(special number) COVID-19, 29-33. doi: https://doi.org/10.22201/fm.14058871p.2020.0.77315.
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., Xia, J., Yu, T., Zhang, X., & Zhang, L. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novelcoronavirus pneumonia in Wuhan, China: A descriptive study. Lancet, 395(10223), 507-513. doi: https://doi.org/10.1016/S0140-6736(20)30211-7.
Guan, W., Ni, Z., Hu, Y., Liang, W., Ou, C., He, J., Liu, L., Shan, H., Lei, C., Hui, D., Du, B., Li, L., Zeng, G., Yuen, K., Chen, R., Tang, C., Wang, T., Chen, P., Xiang, J., Li, S., et al. (2020). Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med, 382, 1708-1720. doi: https://doi.org/10.1056/NEJMoa2002032.
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan., G, Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu ,W., Xie, X., Yin, W., Li, H., Liu, M., Xiao, Y., et al. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 395, 497-506. doi: https://doi.org/10.1016/S0140-6736(20)30183-5.
Motta, J., Novoa, D., Gómez, C., Moreno, J., Vargas, L., Pérez, J., Milla, H., & Arango, A. (2020). Prognostic factors in hospitalized patients diagnosed with SARS-CoV2 infection in Bogotá, Colombia. Biomédica, 40(Supl.2), 116-130. doi: https://doi.org/10.7705/biomedica.5764.
Bastidas, G., & Rojas, A. (2021). COVID-19 an emerging disease in the context of the transversality of quaternary care. Family Care, 28(3), 227-228. doi: https://doi.org/10.22201/fm.14058871p.2021.3.79590.
Grasselli, G., Zangrillo, A., Zanella, A., Antonelli, M., Cabrini, L., Castelli, A., Cereda, D., Coluccello, A., Foti, G., Fumagalli, R., Iotti, G., Latronico, N., Lorini, L., Merler, S., Natalini, G., Piatti, A., Ranieri, M., Scandroglio, A., Storti, E., Cecconi, M., Pesenti, A., & COVID-19 Lombardy ICU Network. (2020). Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region, Italy. JAMA, 323, 1574-1581. doi: https://doi.org/ 10.1001/jama.2020.5394.
Wu, C., Chen, X., Cai, Y., Xia, J., Zhou, X., Xu, S., Huang, H., Zhang, L., Zhou, X., Du, C., Zhang, Y., Song, J., Wang, S., Chao, Y., Yang, Z., Xu, J., Zhou, X., Chen, D., Xiong, W., Xu, L., et al. (2020). Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med, 2020; 180:934-943. doi: https://doi.org/10.1001/jamainternmed.2020.0994.
Xie, J., Tong, Z., Guan, X., Du, B., & Qiu, H. (2020). Clinical characteristics of patients who died of coronavirus disease 2019 in China. JAMA Netw Open, 3, e205619. doi: https://doi.org/10.1001/jamanetworkopen.2020.5619.
Zhao, M., Wang, M., Zhang, J., Ye, J., Xu, Y., Wang, Z., Ye, D., Liu, J., & Wan, J. (2020). Advances in the relationship between coronavirus infection and cardiovascular diseases. Biomed Pharmacother, 127, 110230. doi: https://doi.org/10.1016/j.biopha.2020.110230.
Acosta, G., Escobar, G., Bernaola, G., Alfaro, J., Taype, W., Marcos, C., & Amado, J. (2020) Characterization of patients with severe COVID-19 treated at a national reference hospital in Peru. Rev Peru Med Exp Public Health, 37(2), 253-258. doi: https://doi.org/10.17843/rpmesp.2020.372.5437.
Llaro, S., Gamarra, V., & Campos, C. (2020). Clinical-epidemiological characteristics and survival analysis in deaths from COVID-19 treated in establishments of the Sabogal-Callao Network 2020. Medical Horizon, 20(2), e1229. doi: https://doi.org/10.24265/horizmed.2020.v20n2.03.
Li, X., Xu, S., Yu, M., Wang, K., Tao, Y., Zhou, Y., Shi, J., Zhou, M., Wu, B., Yang, Z., Zhang, C., Yue, J., Zhang, Z., Renz, H., Liu, X., Xie, J., Xie, M., & Zhao, J. (2020). Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. J Allergy Clin Immunol, 146, 110-118. doi: https://doi.org/10.1016/j.jaci.2020.04.006.
Ma, C., Gu, J., Hou, P., Zhang, L., Bai, Y., Guo, Z., Wu, H., Zhang, B., Li, P., & Zhao, X. (2020). Incidence, clinical characteristics and prognostic factor of patients with COVID-19: a systematic review and meta-analysis. MedR-xiv. doi: https://doi.org/10.1101/2020.03.17.20037572,03.17.20037572.7.
Yang, X., Yang, Q., Wang, Y., Wu, Y., Xu, J., Yu, Y., & Shang, Y. (2020). Thrombocytopenia and its association with mortality in patients with COVID-19. J Thromb Haemost, 18, 1469-1472. doi: https://doi.org/10.1111/jth.14848.
Valenzuela, K., Espinoza, A., & Quispe, J. (2021). Mortality and prognostic factors in patients hospitalized for COVID-19 in the Intermediate Care Unit of a public hospital in Lima, Peru. Medical Horizon, 21(1), e1370. doi: https://doi.org/10.24265/horizmed.2021.v21n1.05.
Azkur, A., Akdis, M., Azkur, D., Sokolowska, M., van de Veen. W., Brüggen, M., O´Mahany, L., Gao, Y., & Akdis, C. (2020). Immune response to SARS-CoV-2 and mechanisms of immunopathological changes in COVID-19. Allergy, 2020; 75:1564-1581. doi: https://doi.org/10.1111/all.14364.
Gómez-Antúnez, M., Muiño-Míguez, A., Bendala-Estrada, A., Maestro de la Calle, G., Monge-Monge, D., Boixeda, R., Ena, J., Mella-Pérez, C., Anton-Santos, J., & Lumbreras-Bermejo, C. (2021). Clinical characteristics and prognosis of COPD patients hospitalizedwith SARS-CoV-2. Int J Chron Obstruct Pulmon Dis, 15, 3433-3445. doi: https://doi.org/10.2147/COPD.S276692.
Jain, V., & Yuan, J. (2020). Predictive symptoms and comorbidities for severe COVID-19 and intensive care unit admission: a systematic review and meta-analysis. Int J Public Health, 65, 533-546. doi: https://doi.org/10.1007/s00038-020-01390-7.8.
Tamara, A., & Tahapary, D. (2020). Obesity as a predictor for a poor prognosis of COVID-19: A systematic review. Diabetes Metab Syndr, 14:655-659. doi: https://doi.org/10.1016/j.dsx.2020.05.020.
Gupta, R., Harrison, E., Ho, A., Docherty, A., Knight, S., van Smeden, M., Abubakar, I., Lipman, M., Quartagno, M., Pius, R., Buchan, I., Carson, G., Drake, T., Dunning, J., Fairfield, C., Gamble, C., Green, C., Halpin, S., Hardwick, H., Holden, K., et al. (2021). Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: A prospective cohort study. Lancet Respir Med, 9(4), 349-359. doi: https://doi.org/10.1016/S2213-2600(20)30559-2.
Rubio, R., Lepe, E., & Viloria, M. (2020). Prognostic factors for severity of SARS-CoV-2 infection. Adv Lab Med, 2(2), 259-265. https://doi.org/10.1515/almed-2020-0069.
Jin, Y., Cai, L., Cheng, Z., Cheng, H., Deng, T., Fan, Y., Fang, C., Huang, D., Huang, L., Huang, Q., Han, Y., Hu, B., Hu, F., Li, B., Li, Y., Liang, K., Lin, L., Luo, L., Ma, J., Ma, L., et al. (2020). A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia. Mil Med Res, 7(1), 4. doi: https://doi.org/10.1186/s40779-020-0233-6.
Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., Wu, Y., Zhang, L., Yu, Z., Fang, M., Yu, T., Wang, Y., Pan, S., Zou, X., Yuan, S., & Shang, Y. (2020). Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: A single-centered, retrospective, observational study. Lancet Respir Med, 8, 475-481. doi: https://doi.org/10.1016/S2213-2600(20)30079-5.
Zhang, G., Zhang, J., Wang, B., Zhu, X., Wang, Q., & Qiu, S. (2020). Analysis of clinical characteristics and laboratory findings of 95 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a retrospective analysis. Respir Res, 21(1), 74. doi: https://doi.org/10.1186/s12931-020-01338-8.
Uranga, A., Villanueva, A., Lafuente, I., González, N., Legarreta, M., Aguirre, U., España, P., Quintana, J., García-Gutiérrez, S., & workgroup COVID-19-Osakidetza. (2022). Risk factors for clinical deterioration in patients admitted for COVID-19: a case-control study. Rev Clin Esp, 222(1):22-30. doi: https://doi.org/10.1016/j.rceng.2021.04.009.
Downloads
Additional Files
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Journal of Microbiology & Health Education
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
