Neutralizing Antibodies against SARS-CoV-2 in Individuals with Natural Immunity and Vaccinated Individuals Residents of the State of Aragua, Venezuela
Keywords:
SARS-CoV-2, pandemic, neutralizing antibodies, COVID-19, dry immunofluorescence, COVID-19Abstract
The outbreak of the SARS-CoV-2 disease that started in December 2019 has spread worldwide and has become a global pandemic, with over 676 million cases and more than 6 million deaths to date. The rapid spread and the significant damage caused by the virus have caught the attention of healthcare personnel and large corporations, who have sought to control the progression of the disease through the development of various vaccines. One of the goals of vaccine administration is the production of neutralizing antibodies, as they play a key role in the neutralization and elimination of the virus. In this regard, a cross-sectional descriptive study was done to evaluate the presence and concentration of neutralizing antibodies against SARS- CoV-2 using the dry immunofluorescence method in a sample of 48 vaccinated individuals with different doses and anti-SARS-CoV-2 vaccines, these persons also are residents of the state of Aragua. Various variables, such as pre-existing diseases and history of prior infection, were taken into account and obtained through a data collection form, which allowed a comparison of the concentrations of neutralizing antibodies based on the dose and the vaccine administered. With the development of this project, reliable data is now readily available to inform about decision-making regarding the booster effect doses administered over time.
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